D-134 | Drug Induced QT Prolongation- Pharmacology | Rapid revision notes for GPAT
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D-134 | Drug Induced QT Prolongation- Pharmacology | Rapid revision notes for GPAT
This topic focuses on drug-induced QT interval prolongation, which occurs due to delayed ventricular repolarization mainly by blockade of cardiac potassium (IKr/hERG) channels. It increases the risk of Torsades de Pointes and ventricular arrhythmias. Common causative drugs include Class IA & III antiarrhythmics, macrolide and fluoroquinolone ...
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