Membrane protein targeting and insertion is a fundamental process in cellular biology that ensures proteins are correctly delivered to, and integrated within, the lipid bilayer. Proteins destined for ...

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for ...

Cavities at protein-protein interaction interfaces are often considered "undruggable" because their shallow or large geometries hinder the stable binding by small molecules. A study published ...

Researchers led by  Dr. Xavier Salvatella have uncovered the mechanism by which an experimental drug is able to block intrinsically disordered proteins, which were previously considered “undruggable”.

Cellular membrane proteins play important roles in cellular transport, signaling, and cell-to-cell communication. Malfunction in membrane proteins can lead to serious diseases, such as cancer. However ...

An estimated 20 percent of adults in the US experience chronic pain. 1 To help patients manage their condition, clinicians have employed one main type of pain-relieving drug: opioids. With their ...

Chronic diseases such as type 2 diabetes and inflammatory disorders are a major cause of disease burden and deaths around the world, but their treatment has proven difficult because there may not be ...

Researchers identify tanycytes as a critical mechanism for clearing toxic tau protein from the brain, offering a new target ...

Panelists discuss how amyloid-targeting therapies for Alzheimer disease represent a breakthrough drug class that works by binding to and removing beta-amyloid plaques through various mechanisms, ...