Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a protein and alter its function. A team at HZB has now investigated the Nsp1 ...

Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function of ...

Chung’s group captured the transition period directly by improving the time resolution of a method called single-molecule ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

Every second, hundreds to thousands of molecules move through thousands of nuclear pores in each of your cells. A new high-definition view reveals the machine in action.

In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...

GBA1 mutations alone do not explain lysosomal dysfunction in PD. Loss of endosomal recycling proteins cripple this lysosomal enzyme. Without a protein called COMMD3, cells spit out would-be lysosomal ...

Can the bend of a banana give us insight into cancer? What does the shape of a rice grain have to do with infertility? The ...

Our single-celled ancestor lived in a world without plants, animals or oxygen-rich oceans. Yet, this seemingly simple microorganism took the first steps toward complex life. From this ancestor emerged ...

Mutations within the Complex Proteins Associated With Set1 (COMPASS) family of histone lysine methyltransferases are frequently found in many human diseases including cancer. Increasingly, these ...