The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the small molecule inhibitor of NEDDylation, ...

The size of a cell's nucleolus may reveal how long that cell, or even the organism it belongs to, will live. Over the past few years, researchers have been piecing together an unexpected link between ...

The nucleolus—a conspicuous but obscure organelle within the cell nucleus—is normally too compact to be studied in detail. Researchers at Case Western Reserve University just learned how to simplify ...

Although known since the 1830s as a round, dark spot in a cell's nucleus, only recently has the nucleolus gotten its full due. Scientists have learned that besides building a cell's protein factories, ...

Biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus. Inside ...

An essential component of living cells, the nucleolus underwent a major evolutionary shift around 300m years ago. Scientists have solved an age-old mystery in biology by discovering a protein found in ...

A nucleolar protein, nucleostemin, is now implicated in the control of stem and cancer cell proliferation. Nucleostemin may modulate p53 function through shuttling between the nucleolus and the ...

Deep within the intricate world of cellular biology, scientists at Weill Cornell Medicine have made a remarkable discovery about aging that could transform our understanding of human longevity. Their ...

RNA, or ribonucleic acid, is a short-lived molecule copied from DNA that enables cells to use genetic information. Specific DNA sequences are copied into RNA, which then delivers these instructions to ...

Inside all living cells, loosely formed assemblies known as biomolecular condensates perform many critical functions. However, it is not well understood how proteins and other biomolecules come ...