Loop diuretics are widely used in the management of edema and heart failure. They are also widely misunderstood. The reason is this: Loop diuretics are often prescribed in a dose-dependent strategy.

Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. In a prospective, double-blind, ...

Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of ...

Over time, the retention of sodium leads to crackles, peripheral edema, hepatomegaly with ascites, increased blood volume, and increased cardiac filling pressures. Although diuretics do not directly ...