CSHL’s Krainer lab used a technique called live-cell fluorescence imaging to observe the DDX23 enzyme (above, in green) in action. Together with the critical regulator protein SRSF1, DDX23 helps set ...
Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...
The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...
The researchers' analysis suggests that this type of splicing arose in a common ancestor of plants, animals, and fungi, but it was lost from fungi soon after they diverged from plants and animals. "A ...
RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...
Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have ...
Scientists at the Hospital for Sick Children (SickKids) and the University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition ...
Omics technologies have enabled researchers to study the molecular functions of human tissues. But some tissues—like the brain—are harder to access than others. Because of the limited access to living ...
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