GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...

Researchers have found a protein that connects GLP-1 agonist drugs to long-term, broad genomic responses that can promote pancreatic health and resilience. GLP-1s are building a reputation as ‘wonder ...

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...

New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

Genetics is the study of genes and how they influence characteristics and health. Through a variety of technological methods, environmental factors, and lifestyle choices, it is possible to alter some ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

Diet can leave lasting epigenetic marks that reshape gene expression, metabolic pathways, and disease susceptibility across the lifespan. These diet-driven molecular changes may create a form of ...

Small (left) and large (right) condensates of the Mediator complex inside nuclei of a pancreatic beta cell-derived cell line. Salk researchers discovered that GLP-1s interact with the multi-protein ...