We developed a genome-wide allele-specific methylation framework using long-read sequencing to characterize intergenerational epigenetic inheritance in mice. This framework revealed non-Mendelian ...

It has been hypothesized that the inheritance of epigenetic traits, such as DNA methylation, may be more prevalent than is currently established 1,2. This phenomenon could help explain poorly ...

Genetic information in the DNA and modifications, such as DNA methylation, define the epigenetic landscape and phenotype and show both Mendelian and non-Mendelian heredity. Scientists have long known ...

For more than a century, heredity has been framed through the tidy logic of Mendel's pea plants: traits pass from parent to offspring by fixed genetic rules. But a new mouse study suggests that ...