Researchers have engineered a new class of adenine base editors that reduce unwanted bystander mutations by two to three times compared to the widely used ABE8e, while preserving the editing power ...

The trajectory of base editing has been remarkable, progressing from the laboratory to patient care, treating debilitating or terminal illnesses, in less than a decade. A type of gene editing that ...

Point mutations change one or very few nucleotides in DNA, but they cause an estimated 30,000 genetic diseases in humans. For example, children born with Progeria age rapidly and die before adulthood, ...

Like base editing, prime editing offers a safer way to genome editing by relying on a nickase enzyme that “nicks” one DNA strand at a time, rather than cutting both simultaneously. Then, with the ...

Proteins carry out exceptionally diverse molecular functions—even though they are all built on an unvarying polyamide backbone. How much more chemical diversity might be unlocked by editing that ...

A lot of videos fail in a surprisingly quiet way. The footage is sharp, the subject is clear, the idea is decent, and still the final result feels slightly off ...