Houston Methodist scientists have uncovered an unexpected side of a protein best known for its link to brain diseases. The ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study High levels of DNA replication stress and defects in the ...

Yuan He aims to understand how cells read and repair their genomes. His research encompasses two primary areas: transcription, in which genetic information is copied from DNA into messenger RNA, and ...

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research. In spite of ...

In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology in Leipzig analyzed the impact of more than 2,000 clinically approved drugs on DNA repair and CRISPR genome editing ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...