The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...

Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat ...

Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a specialized population of neutrophils in the skin that produce extracellular matrix components, helping ...

In a study published in Cell Stem Cell, researchers led by Profs. DAI Jianwu and ZHAO Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have ...

Scientists have developed a synthetic extracellular matrix (ECM) that can support the growth of a mini endometrium in a dish for at least two weeks. The endometrium -- the mucosal lining of the uterus ...

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to ...

In cell and animal models of amyotrophic lateral sclerosis (ALS), the expression of toxic dipeptides in neurons led to changes in the extracellular matrix (ECM) as a protective response. The authors ...

Senescence. It’s a beautiful-sounding word whose tones suggest it should be a perfume or an essential oil. But that’s not even close. Senescence is the loss of a cell’s power to divide and grow, thus ...