Nature

Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency

The analysis of protein topology for the human GDP-fucose transporter predicts 10 transmembrane domains with the N and carboxy termini exposed to the cytosol (Fig. 3). The four transmembrane domains 3 ...
Nature

Triallelic Complementation and the Subunit Structure of Enzymes

INTERALLELIC complementation makes a genetical approach to the problem of enzyme structure possible. It is expressed as the partial to complete restoration of the normal phenotype in heterocaryons or ...