A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment ...

For many lung cancer patients, the best treatment options involve checkpoint inhibitors. These immunotherapy drugs unleash a patient’s immune system against their disease and can yield dramatic ...

Many cancer cells duck the immune system’s T cells by displaying programmed death-ligand 1 (PD-L1), a cell-surface protein that engages programmed cell death protein 1 (PD-1), another cell-surface ...

Just like a runaway eighteen-wheeler on the interstate is a scary sight to behold, an immune system without brakes can quickly transform from a cherished protector to a host’s worst nightmare. To ...

Scientists at Albert Einstein College of Medicine have developed a new anticancer strategy that they suggest could bolster the effectiveness of immune-checkpoint therapy. The team said their findings ...