Modifications of the chromatin are crucial for the regulation of nearly all DNA-templated biological processes. Single-cell chromatin modification profiling can be used to assess chromatin ...

Proof-of-concept trial in a single patient shows that cells can survive transplantation without immunosuppression ...

Epigenetics is the study of how our cells alter their function by modifying gene expression in our genetic code or deoxyribonucleic acid (DNA). In our cells, DNA is constantly being used to generate ...

Omalizumab, both as a monotherapy and for oral immunotherapy (OIT), modulates specific T cell and dendritic cell (DC) subsets, increasing patient's reaction thresholds to common food allergens, ...

In clinical settings, prophylactic DLI is usually performed in patients without GVHD after 2 months off immunosuppression if the chimerism is not fully converted to the donor type or is being lost. In ...

The human body has to protect itself from pathogens and infectious agents, and there are a variety of ways for the immune system to sense foreign invaders, and react to the threats they may pose. But ...

A new tool called SigRM helps researchers study RNA modifications in individual cells, improving our understanding of how genes are regulated. Researchers have developed a new tool that will help ...

There is an explosion of single-cell genomics profiling technologies. Although major advances have been made in measuring gene expression and DNA accessibility, assays specific to epigenetic ...

When cells are healthy, we don't expect them to suddenly change cell types. A skin cell on your hand won't naturally morph into a brain cell, and vice versa. That's thanks to epigenetic memory, which ...